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bet family members  (MedChemExpress)


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    MedChemExpress bet family members
    Initial screening of select <t>BET</t> inhibitors to determine their effects on angiogenesis in the chick embryo CAM model. Representative inhibitory results on the growth of blood vessel branches by DMSO (A) or the selected BRD4 inhibitors (B) , which showed strong positive inhibition (+++) of angiogenesis in the chick embryo CAM model. Each BET inhibitors (50 μg/ml) or DMSO was added directly onto the live 9-day-old chick embryo CAM model and incubated for 48 h. Then, the blood vessel network in the chicken embryo CAM was photographed by an OPTPRO 2007 image system. (C) The statistical results of microvessel density (MVD) analysis of the chick embryo CAM model treated with the selected BET inhibitors are shown in <xref ref-type= Table 1 . (D) Structures of (+)-JQ1 (1) (positive control), ZL0454 (2), MS436 (3), and ZL0513 (7). * P < 0.05 compared with the DMSO group, # P < 0.05 compared with the (+)-JQ1 (1) positive control group. " width="250" height="auto" />
    Bet Family Members, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/bet family members/product/MedChemExpress
    Average 93 stars, based on 2 article reviews
    bet family members - by Bioz Stars, 2026-02
    93/100 stars

    Images

    1) Product Images from "A Bromodomain-Containing Protein 4 (BRD4) Inhibitor Suppresses Angiogenesis by Regulating AP-1 Expression"

    Article Title: A Bromodomain-Containing Protein 4 (BRD4) Inhibitor Suppresses Angiogenesis by Regulating AP-1 Expression

    Journal: Frontiers in Pharmacology

    doi: 10.3389/fphar.2020.01043

    Initial screening of select BET inhibitors to determine their effects on angiogenesis in the chick embryo CAM model. Representative inhibitory results on the growth of blood vessel branches by DMSO (A) or the selected BRD4 inhibitors (B) , which showed strong positive inhibition (+++) of angiogenesis in the chick embryo CAM model. Each BET inhibitors (50 μg/ml) or DMSO was added directly onto the live 9-day-old chick embryo CAM model and incubated for 48 h. Then, the blood vessel network in the chicken embryo CAM was photographed by an OPTPRO 2007 image system. (C) The statistical results of microvessel density (MVD) analysis of the chick embryo CAM model treated with the selected BET inhibitors are shown in <xref ref-type= Table 1 . (D) Structures of (+)-JQ1 (1) (positive control), ZL0454 (2), MS436 (3), and ZL0513 (7). * P < 0.05 compared with the DMSO group, # P < 0.05 compared with the (+)-JQ1 (1) positive control group. " title="Initial screening of select BET inhibitors to determine their effects on angiogenesis in ..." property="contentUrl" width="100%" height="100%"/>
    Figure Legend Snippet: Initial screening of select BET inhibitors to determine their effects on angiogenesis in the chick embryo CAM model. Representative inhibitory results on the growth of blood vessel branches by DMSO (A) or the selected BRD4 inhibitors (B) , which showed strong positive inhibition (+++) of angiogenesis in the chick embryo CAM model. Each BET inhibitors (50 μg/ml) or DMSO was added directly onto the live 9-day-old chick embryo CAM model and incubated for 48 h. Then, the blood vessel network in the chicken embryo CAM was photographed by an OPTPRO 2007 image system. (C) The statistical results of microvessel density (MVD) analysis of the chick embryo CAM model treated with the selected BET inhibitors are shown in Table 1 . (D) Structures of (+)-JQ1 (1) (positive control), ZL0454 (2), MS436 (3), and ZL0513 (7). * P < 0.05 compared with the DMSO group, # P < 0.05 compared with the (+)-JQ1 (1) positive control group.

    Techniques Used: Inhibition, Incubation, Positive Control



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    bet family members  (MedChemExpress)
    93
    MedChemExpress bet family members
    Initial screening of select <t>BET</t> inhibitors to determine their effects on angiogenesis in the chick embryo CAM model. Representative inhibitory results on the growth of blood vessel branches by DMSO (A) or the selected BRD4 inhibitors (B) , which showed strong positive inhibition (+++) of angiogenesis in the chick embryo CAM model. Each BET inhibitors (50 μg/ml) or DMSO was added directly onto the live 9-day-old chick embryo CAM model and incubated for 48 h. Then, the blood vessel network in the chicken embryo CAM was photographed by an OPTPRO 2007 image system. (C) The statistical results of microvessel density (MVD) analysis of the chick embryo CAM model treated with the selected BET inhibitors are shown in <xref ref-type= Table 1 . (D) Structures of (+)-JQ1 (1) (positive control), ZL0454 (2), MS436 (3), and ZL0513 (7). * P < 0.05 compared with the DMSO group, # P < 0.05 compared with the (+)-JQ1 (1) positive control group. " width="250" height="auto" />
    Bet Family Members, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/bet family members/product/MedChemExpress
    Average 93 stars, based on 1 article reviews
    bet family members - by Bioz Stars, 2026-02
    93/100 stars
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    Image Search Results


    Initial screening of select BET inhibitors to determine their effects on angiogenesis in the chick embryo CAM model. Representative inhibitory results on the growth of blood vessel branches by DMSO (A) or the selected BRD4 inhibitors (B) , which showed strong positive inhibition (+++) of angiogenesis in the chick embryo CAM model. Each BET inhibitors (50 μg/ml) or DMSO was added directly onto the live 9-day-old chick embryo CAM model and incubated for 48 h. Then, the blood vessel network in the chicken embryo CAM was photographed by an OPTPRO 2007 image system. (C) The statistical results of microvessel density (MVD) analysis of the chick embryo CAM model treated with the selected BET inhibitors are shown in <xref ref-type= Table 1 . (D) Structures of (+)-JQ1 (1) (positive control), ZL0454 (2), MS436 (3), and ZL0513 (7). * P < 0.05 compared with the DMSO group, # P < 0.05 compared with the (+)-JQ1 (1) positive control group. " width="100%" height="100%">

    Journal: Frontiers in Pharmacology

    Article Title: A Bromodomain-Containing Protein 4 (BRD4) Inhibitor Suppresses Angiogenesis by Regulating AP-1 Expression

    doi: 10.3389/fphar.2020.01043

    Figure Lengend Snippet: Initial screening of select BET inhibitors to determine their effects on angiogenesis in the chick embryo CAM model. Representative inhibitory results on the growth of blood vessel branches by DMSO (A) or the selected BRD4 inhibitors (B) , which showed strong positive inhibition (+++) of angiogenesis in the chick embryo CAM model. Each BET inhibitors (50 μg/ml) or DMSO was added directly onto the live 9-day-old chick embryo CAM model and incubated for 48 h. Then, the blood vessel network in the chicken embryo CAM was photographed by an OPTPRO 2007 image system. (C) The statistical results of microvessel density (MVD) analysis of the chick embryo CAM model treated with the selected BET inhibitors are shown in Table 1 . (D) Structures of (+)-JQ1 (1) (positive control), ZL0454 (2), MS436 (3), and ZL0513 (7). * P < 0.05 compared with the DMSO group, # P < 0.05 compared with the (+)-JQ1 (1) positive control group.

    Article Snippet: The stereoisomer of active (+)-JQ1, (−)-JQ1, which fails to significantly interact with any bromodomain of BET family members and was purchased from MedChemExpress (MCE, Monmouth Junction, NJ, USA) as a negative control.

    Techniques: Inhibition, Incubation, Positive Control